| Basic and Translational Urology | ||
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| International Braz J Urol
Official Journal of the Brazilian Society of Urology
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Vol. 36 (1): 086-094, January - February, 2010 | |
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THE EFFECT OF ALPHA-BLOCKER TREATMENT ON BLADDER HYPOXIA INDUCIBLE FACTOR-1 ALPHA REGULATION DURING LOWER URINARY TRACT OBSTRUCTION
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GEORGE KORITSIADIS, STAVROS I. TYRITZIS, GEORGE KOUTALELLIS, ANDREAS C. LAZARIS, KONSTANTINOS STRAVODIMOS (EDITORIAL COMMENTS BY Y. CHUANG AND M.B. CHANCELLOR)
Department of Urology (GK, SIT, GK, KS) and Pathology (ACL), Athens University Medical School, LAIKO Hospital, Athens, Greece |
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Abstract
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| Aims: To determine whether a1-blocker treatment, in chronic bladder outlet obstruction (BOO), influences bladder tissue ischemia. Materials and Methods: This prospective study included 60 patients with BOO, of which 40 were under a1-blocker medication and 20 without treatment. Patients underwent transurethral resection of the prostate (TURP) or suprapubic prostatectomy (SPP). Ten patients with non-muscle invasive bladder cancer underwent transurethral resection of the bladder tumor and served as the control group. Tissue specimens were immunohistochemically stained for hypoxia inducible factor-1a (HIF-1a). Results: Bladder tissue from obstructed subjects showed high immunoreactivity to HIF-1a. The specimens from the control group, showed no or weak, mainly cytoplasmic immunoreactivity to HIF-1a. Patients under a -blocker treatment did not differ in the number of HIF-1a positive cells compared to subjects with no treatment (median number 86.8 [20-150] and 88.6 [0-175], respectively) (p > 0.05). The lowest bladder pressure at which HIF-1a was up regulated, was detected at detrusor pressure Qmax (PdetQmax) = 60 cm H2O. Conclusions: Treatment with a-blockers in obstructed patients considered as non-responders, does not result in HIF-1a down regulation, thus bladder continues to be under chronic stress. | ||
| Key
Words: bladder; bladder outlet obstruction; hypoxia inducible factor-1; ischemia; alpha-blockers
Int Braz J Urol. 2010; 36: 86-94 |
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